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Your Trusted Partner for Comprehensive Healthcare Solutions
St. Luke's has served the St. Louis area for over 150 years as a faith-based, nonprofit healthcare provider dedicated to improving community well-being. Our compassionate team delivers high-quality, nationally recognized care across 60+ specialties, achieving exceptional patient satisfaction. From our origins as a single hospital, we've expanded to a 493-bed facility in Chesterfield, MO, and nearly 30 outpatient locations. As the region's only independent healthcare provider, we maintain strategic partnerships like our exclusive alliance with Cleveland Clinic's Heart, Vascular & Thoracic Institute. Our leadership in community health education includes Spirit of Women programs focused on women's wellness.

With a heritage of excellence in cancer care, cardiology, neurology, orthopedics, and women's health, we partner with patients to achieve optimal health outcomes. Our values of human dignity, compassion, justice, excellence, and stewardship guide every decision. We prioritize patient safety and welcome feedback through dedicated relations channels. Recognized as one of America's Best Cancer Hospitals and Missouri's top cardiac surgery program, we combine advanced technology with personalized care.
Services
Cancer Care Heart and Vascular Institute Neurology and Neurosurgery Orthopedics Women's Services Emergency Care Primary Care Urgent Care Imaging Services Therapy Programs
Highlights and features
  • We offer over 150 years of healthcare expertise in the St. Louis region
  • Our specialists are nationally recognized in 60+ medical disciplines
  • We maintain exclusive partnerships with top institutions like Cleveland Clinic
  • Our patient-centered approach prioritizes personalized care and satisfaction
  • We combine cutting-edge technology with community-focused health initiatives
Services
Cancer Care
St. Luke's Center for Cancer Care provides personalized treatment using the latest advances in cancer therapy. Our multidisciplinary team offers comprehensive care for all cancer types, with rapid patient access and exceptional outcomes. Recognized as one of America's Best Cancer Hospitals, we combine advanced technology with compassionate support services.
Heart and Vascular Institute
Our nationally renowned Heart & Vascular Institute offers comprehensive cardiovascular care, including Missouri's top-ranked cardiac surgery program. We provide advanced imaging, interventional procedures, and surgical treatments, with exclusive partnership access to Cleveland Clinic's expertise. Our program focuses on optimal patient outcomes and heart health management.
Neurology and Neurosurgery
The Orthwein Brain & Spine Center treats neurological conditions and spine disorders with expert care. Our team specializes in treating neck/back pain, headaches, and complex neurological conditions using advanced diagnostic tools and minimally invasive surgical techniques for improved patient recovery.
Women's Services
St. Luke's comprehensive women's health program covers gynecological care, maternity services, and specialized programs for breast and pelvic health. As a Spirit of Women hospital, we offer educational resources and wellness initiatives tailored to women's health needs across all life stages.
Orthopedics
Our orthopedic specialists provide evidence-based treatments for musculoskeletal conditions, including joint replacement, sports medicine, and rehabilitation services. The program emphasizes personalized care plans and advanced surgical techniques to restore mobility and improve quality of life for patients with bone and joint conditions.
Questions
What medical services does St. Luke's offer?
We provide comprehensive care across 60+ specialties including cancer treatment, heart care, neurology, orthopedics, women's health, emergency services, and primary care through our hospital and 30+ outpatient locations.
How can I schedule an appointment?
Use our online scheduling system for many services, contact our Physician Referral team at 314-205-6060, or visit our website to find and book appointments with available providers across our network.
What emergency care options are available?
Our Chesterfield hospital has a full Emergency Department, with additional urgent care centers across the region offering walk-in services for non-life-threatening conditions during extended hours.
Do you offer virtual healthcare options?
Yes, St. Luke's provides virtual visits through our telehealth platform for convenient access to medical consultations and follow-up appointments with participating providers across multiple specialties.
What payment options are available?
We accept major insurance plans, offer self-pay discounts, and have financial counselors available to help with billing questions. Payment plans can be arranged through our billing department at 314-205-6880.
Reviews (5)
Sandra S.
Jun 01, 2022 Report
I was number three when they opened. Numbers one and two are gone (saw one leave, heard two leave). I sat in a room for 25 minutes waiting. I could then, and do now, hear the staff outside chatting, being social. I am still waiting to see the doctor. At least the X-ray is finished but who knows how many places in the doctor's lineup I was skipped over while that was happening. I knew in my gut I should have gone somewhere else but didn't listen. There's no 'urgency' to this place.
Danny Penn
May 08, 2022 Report
This hospital is shady. We have been double billed for services that we both did and DID NOT receive. When we call to dispute, we continually get the runaround and/or told the one person can't look up an account, only to find out they definitely can. Time after time we are proven correct, as charges we contest suddenly disappear, without so much as a phone call to tell us. We have had refunds owed to us because of the over-billing, but the hospital did not contact us to begin repayment. I would not trust this hospital to give me a bandaid and charge me correctly.
Geri Goeggel
Apr 12, 2022 Report
My past Husband was in for 6 weeks they made him comfortable I was pleased. I was just in for few days such good care always showed up in minutes not ever long. Respect I APPRECIATE QUALITY 1ST CLASS.
Michelle Markos
Feb 21, 2022 Report
My father was admitted through the ER on a Sunday and my mother the following Monday. Ben an ER nurse took care of both of them. I can't say enough good things about him. He was compassionate and informative. Unfortunately my mom was at the end of her life. The ER staff and doctor on duty that day were all so kind. My mom was transferred to a room to be made comfortable until she passed. Nellie/Nell took over my mom's care. She was a godsend for our family. So caring going above and beyond. If there are angels on earth she is one of them. Thank you for taking care of my mom.
Kate'O.
Feb 13, 2022 Report
I came from Oklahoma to come to this facility just to be treat by Dr. DeRosa (who is out of this world top notch). The hospital is very well laid out in a very nice community. Everything is clearly marked, and navigating around the facility is easy. The hospital itself is clean, bright, open and welcoming. The staff were nothing but extraordinary to me from the lab staff, ultrasound techs, nurses and registration.

I'm so very happy and pleased with how transparent billing was for me and very easy to understand. Everyone I encountered was so kind and patient with me. I'm so thankful for everyone at St Luke's and for the remarkable care I received. Highly recommend!